MBI Videos
Philip Maini
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Philip MainiCollective motion is ubiquitous in biology, occurring in normal development, wound healing, and pathological cases, such as cancer. Here, I will review work that we have done on three problems: neural crest cell invasion, angiogenesis, and epithelial sheet movement. Each of these requires a different modelling paradigm, ranging from agent-based models, to partial differential equations. I will show how these problems lead to new mathematical challenges and how, with close collaboration with experimentalists, in some cases we have unearthed new biology.
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Philip MainiThe collective movement of cells in tissue is vital for normal development but also occurs in abnormal development, such as in cancer. We will review three different models: (i) A vertex-based model to describe cell motion in the early mouse embryo; (ii) A individual-based model for neural crest cell invasion; (iii) A model for acid-mediated tumour invasion.
In each case we shall use the model to answer important issues concerning biology. For example, in (i) we shall propose a role for rosette formation, in (ii) we propose that two cell types are necessary for successful invasion, and in (iii) we shall show how the model suggests possible therapeutic strategies for tumour control. -
Philip MainiAbstract not submitted